Article Watch: September 2015

In the September 2015 issue

Day Saturday , September 19 , 2015

Genome editing is a useful tool for the characterization of gene function as well as the creation of disease-related mutations. Through the use of clustered regularly interspaced short palindromic repeats (CRISPR), we have successfully induced mutations in zebrafish for the study of four genes known to cause Amyotrophic Lateral Sclerosis (ALS) in humans. The use of genome editing to affect the ...

AIDSFree Prevention Update: September 2015

Repeat Use of Post-Exposure Prophylaxis for HIV among Nairobi-Based Female Sex Workers Following Sexual Exposure Single-Tablet Emtricitabine-Rilpivirine-Tenofovir as HIV Post-Exposure Prophylaxis in Men Who Have Sex with Men Missed Opportunities along the Prevention of Mother-to-Child Transmission Services Cascade in South Africa: Uptake, Determinants, and Attributable Risk (the SAPMTCTE) Impro...

Comments on Statistical Issues in September 2015

One of the simplest and most widely used multiple comparison tests is the Bonferroni adjustment (test). It is applicable to the following situations: 1) Regardless of whether or not the sample sizes of each group are equal. 2) When the family of interest is the particular set of comparisons (not all pair-wise comparisons). We can easily obtain the results of the Bonferroni comparison by multipl...

Detection of macrolide resistant Mycoplasma pneumoniae in England, September 2014 to September 2015.

Mycoplasma pneumoniae infection can cause pneumonia, particularly in children. Global increase in macrolide-resistant M. pneumoniae is of concern due to limited therapeutic options. We describe the detection of macrolide resistance-conferring mutations in 9.3% of 43 clinical specimens where M. pneumoniae was detected in England and Wales from September 2014‒September 2015. This study aims to im...